Creative Biolabs is one of the well-recognized experts who are professional in applying advanced platforms for the development of drug delivery systems. Now we are proud to offer a series of reagents, such as hydrogenated soy phosphatidylcholine to achieve more functions.
In oral drug delivery, coatings and matrix systems are always used to control the drug release rates from the dosage forms. Hydrogenated soy phosphatidylcholine, also known as hydrogenated soybean phosphatidylcholine or HSPC, now has been investigated as a promising excipient for matrix tablets formation. With a series of advantages, such as excellent flow properties and processability by compression, HSPC matrices present great potential to extend drug release regarding drug loading and solubility for oral drug delivery of water-soluble drugs. What's more, HSPC can be used in the preparation of lipid nanoparticles.
Lipoid S Pc-3, also known as PC soybean hydrogenated, is a novel lipoid developed in drug delivery systems. Studies have shown that lipoid S Pc-3 can be served as a coprecipitate carrier to improve the permeability and solubility of ranolazine. According to a series of physical and chemical characterization, lipoid S Pc-3-based coprecipitates of ranolazine (RNZ-SPC-CP) present enhanced extent and rate of ranolazine dissolution (~ 85%) compared to pure ranolazine (~ 21%), as well as enhanced significantly (~ 83%) than pure ranolazine (~ 19%). What's more, lipoid S Pc-3 has been used for the development of gefitinib solid lipid nanoparticles (GFT-SLN) to provide higher antitumor efficacy and better drug distribution in tissues.
Fig 1. Schematic diagram representing the entrapment of pure ranolazine within the polar head of LSPC-3 resulting in the formation of the RNZ-SPC-CP complex. (Telange, 2020)
Phospholipon 80 H and Phospholipon 90 H are both hydrogenated soy phosphatidylcholine. Phospholipon 90 H (P90H) is a novel lipoid that has been used in the construction of a PEGylated microscopic lipospheres delivery system for gentamicin. Multiple physical and chemical characterization tests showed that the encapsulation efficiency (EE%) and loading capacity (LC) is significantly improved. Among them, the low crystallinity of phospholipid 90 H may be an important contributing factor. In summary, using phospholipid 90 H-based lipid drug delivery systems, the problem of poor absorption and gentamicin stability in the oral formulation can be solved.
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