Creative Biolabs specializes in mRNA products and drug delivery systems, offering expert advice and support to advance projects globally. We provide various reagents for mRNA delivery, including liposomes and microspheres, which are crucial for improving drug pharmacokinetics, reducing toxicity, and enhancing therapeutic efficacy.
Hydrogenated soy phosphatidylcholine, derived from soy lecithin through hydrogenation, is widely used in the preparation of liposomes and serves as an important pharmaceutical excipient. It's particularly effective in the formation of matrix tablets due to its excellent flow properties, compressibility, and ability to extend the release of water-soluble drugs. This makes it a valuable component in oral drug delivery systems, especially for drugs that require controlled release and enhanced bioavailability.
Fig 1. "Super" NK cells are liposome functionalized NK cells.1
HSPC has two forms - Phospholipon 80 H and Phospholipon 90 H, which are widely used in the development of liposomal drug delivery systems. Liposomes made from a mixture of soy phosphatidylcholine (P50) and hydrogenated soy phosphatidylcholine (P90H) have high drug encapsulation efficiency and retention. This formulation helps to maintain drug stability and improve its release profile. In addition, nanocarriers formed by combining PEG-DMA, HSPC, and cholesterol provide a stable and biocompatible solution for drug delivery. These "gel-entrapped liposome" structures exhibit enhanced stability, controlled release properties, and biocompatibility, making them ideal for a variety of therapeutic applications.
In oral drug delivery, HSPC has been studied as a key material for creating matrix systems that control drug release. Its unique properties, such as low crystallinity and resistance to enzymatic degradation, make it an ideal choice for extending drug release and improving drug absorption. This is especially important for water-soluble drugs, as they can benefit from HSPC's ability to control the release rate and improve therapeutic outcomes. Phospholipon 90 H has been successfully incorporated into PEGylated lipospheres for the oral delivery of gentamicin, significantly improving drug stability and absorption.
Creative Biolabs continues to leverage cutting-edge technology and expertise to provide high-quality products and solutions for drug delivery. For more detailed information, customers are encouraged to contact the company for further inquiries.
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