Creative Biolabs has years' experience in mRNA products and will offer you the best advice and support to help advance your projects. We provide various reagents regarding mRNA delivery for our customers all over the world.
Recently, various drug carrier systems, including liposomes and microspheres, have been investigated for therapeutic applications because of their ability to alter the pharmacokinetics and reduce the toxicity of the associated drugs. The Liposomes-based delivery system has great promise because it can improve pharmacokinetics and pharmacodynamics, decrease toxicity, enhance therapeutic efficacy against pathogens, and improve drug-target selectivity.
Fig.1 The liposome-based on HSPC. (Lee, 2018)
HSPC is recently investigated as a promising excipient to form matrix tablets by direct compression. HSPC has excellent flow properties, processability by compression, and sufficient potential to extend the release of water-soluble drugs. Moreover, matrices are not prone to enzymatic digestion due to the small specific area available.
In one study, liposomes were prepared using a mixture of soy phosphatidylcholine (P50) and hydrogenated soy phosphatidylcholine (P90H). Liposomes showed the capability to incorporate the high quantity of drugs retained in high amounts during the coating procedure. Indeed, this formulation of liposomes showed a high encapsulation efficiency and a good capability of retaining drugs.
In another study, PEG-DMA, HSPC, and cholesterol can be combined to form nanocarriers. In addition to their high versatility, these gel-in-liposomes constructs combine enhanced stability with release properties and biocompatibility. This formulation meets the requirement for an effective drug delivery system and offers a new way of envisioning lipidic vesicles.
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