Sodium taurocholate (STC) is the sodium salt of taurocholic acid, a bile acid consisting of cholic acid and taurine. STC is a detergent useful for the solubilization of lipids and membrane-bound proteins.
Fig.1 Molecular Structure of STC.
The preparation of SLN was performed using the solvent emulsification/evaporation method. STC is often used as a penetration enhancer for several eye preparations studied earlier. Therefore, the excipient is selected as a cosurfactant for preparing lipid nanoparticles, and stearic acid and tristearate are used as lipid carriers. The properties of the optimized SLN-6 meet the prerequisites of ideal ophthalmic preparation, such as submicron size, narrow PDI, high zeta potential, and good encapsulation efficiency. In vivo study confirmed that VAC from SLN-6 had better ocular bioavailability than drug solution. Hence, the study demonstrated the potential of lipid nanocarriers in the efficient ocular delivery of hydrophilic molecules (like VAC).
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