Li Bowen of the University of Toronto and Daniel Anderson of the Massachusetts Institute of Technology published a research paper entitled “Accelerating ionizable lipid discovery for mRNA delivery using machine learning andRead More…
So far, over 170 types of RNA modifications have been identified, and these modifications are widely distributed in non-coding RNAs. With the advancement of detection techniques, various chemical modifications have been detectedRead More…
Multiple myeloma is an incurable bone marrow cancer that causes over 100,000 deaths annually. Known for its rapid and deadly spread, it is one of the most challenging diseases scientists face today.Read More…
The mRNA vaccine, which is rated as an epoch-making innovation. Instead of injecting inactivated or inactivated viruses into the body, this method employs synthetic genetic fragments to emulate viral attacks and stimulateRead More…
Small nucleic acid drugs are short in length and have fewer than 30nt bases. They mainly act on intracellular mRNA through the principle of base complementary pairing to regulate protein expression soRead More…
With the rapid development of tumor immunotherapy, drugs have been approved at PD-1, CTLA-4, PD-L1, LAG-3 and other immune checkpoints, bringing a lot of enthusiasm for research and development to the industry.Read More…
Like most vaccines, mRNA vaccines need to be injected with syringes, which can be an obstacle for people who are afraid of needles. If the mRNA vaccine can be delivered orally, itRead More…
In recent years, as a new pharmaceutical technology, mRNA has made a breakthrough in the field of infectious diseases and tumor treatment in a short time. However, how to deliver mRNA drugsRead More…
The structure of mRNA can be divided into five parts, starting from the 5 ‘end, namely, 5’ cap, 5 ‘non-transcriptional region (UTR), open reading frame encoding antigen, 3’UTR and polyadenine tail. EachRead More…