Hepatitis B is the most common serious liver disease caused by hepatitis B virus (HBV) infection. Most adults infected with HBV have little or no symptoms and can rely on the immuneRead More…
At the 2022 annual meeting of the American Association for Cancer Research (AACR), BioNTech released its phase 1 clinical data of CAR-T + CARVac in the treatment of Claudin6 (CLDN6) positive solidRead More…
T cell antigen receptor (TCR) signals can help control the development, activation, and survival of T cells by involving multiple layers and mechanisms regulated by a variety of genes. M6-methyladenosine (m6A) isRead More…
Phenylketonuria (PKU) is an autosomal recessive disease caused by the abnormal metabolism of phenylalanine (Phe). PKU is caused by a mutation in the phenylalanine hydroxylase (PAH) gene. This gene produces a liverRead More…
Advantages mRNA has a unique position in gene therapy and protein therapy, combining the advantages of both therapies while circumventing the challenges faced by both. For example, the difficulty of producing multimericRead More…
An emerging field of mRNA technology is in vivo encoding immune proteins or immunomodulatory proteins that can be used therapeutically, such as antibodies and cytokines. One of the main challenges of proteinRead More…
With the rapid development of tumor immunotherapy, drugs have been approved at PD-1, CTLA-4, PD-L1, LAG-3 and other immune checkpoints, bringing a lot of enthusiasm for research and development to the industry.Read More…
As the mRNA vaccine has achieved great results in the prevention of COVID-19, it has been widely recognized by global researchers. At the same time, the application prospect of mRNA technology inRead More…
Therapeutic mRNA vaccines have developed rapidly in recent years, and they have attracted wide attention as a new choice for tumor treatment. Through precise sequence design, mRNA vaccines can encode one orRead More…
Introduction to Nucleic Acid Drugs Nucleic acid is the general name of DNA and RNA, in which DNA is the basis for storing, copying, and transmitting genetic information, while RNA plays anRead More…