08May/23

Predicting mRNA Degradation by AI models to Improve the Stability of mRNA Vaccines

May 8, 2023mRNA Therapy ResearchAI Predicting, mRNA Vaccinescblmrna

The mRNA COVID-19 vaccine plays a key role in the fight against COVID-19. Because of its rapid production ability and promising results in a number of clinical studies, vaccines and treatments basedRead More…

10Apr/23

One of the Most Popular areas of Small Nucleic Acid Research: siRNA

April 10, 2023mRNA Therapy ReviewsmRNA, siRNAcblmrna

Small nucleic acid drugs are short in length and have fewer than 30nt bases. They mainly act on intracellular mRNA through the principle of base complementary pairing to regulate protein expression soRead More…

02Mar/23

Manganese-Based LNP-mRNA Vaccine Has Strong Immunogenicity

March 2, 2023mRNA Therapy ResearchLNP-mRNA Vaccine, mRNA Deliverycblmrna

A variety of vaccines have been approved to prevent COVID-19, including two mRNA vaccines, Comirnty (BNT162b2) developed by Pfizer / BioNTech and Spikevax (mRNA-1273) developed by Moderna. The mRNA vaccine has playedRead More…

07Feb/23

An Innovative Inhaled mRNA Therapy Possibly Realizes Precise Delivery of mRNA to Lungs

February 7, 2023mRNA Therapy News, mRNA Therapy ResearchLung Cancer, mRNA therapycblmrna

Nucleic acid-based drugs are very adaptable and may encode a wide range of therapeutic proteins for treatment, prevention, or vaccine. Currently, the development and improvement of viral vectors such as lentivirus andRead More…

28Dec/22

Lancet Review: Delivery and Clinical Progress of mRNA Cancer Vaccine

December 28, 2022mRNA Therapy News, mRNA Therapy ResearchmRNA-Based Cancer Vaccinecblmrna

The COVID-19 pandemic makes the mRNA vaccine become the focus of global researchers. The rapid development of the COVID-19 vaccine benefits from years of research on using mRNA vaccines as a cancerRead More…

07Dec/22

For mRNA-LNP Therapeutics Research: Novel FNP Platform Presents Enhanced Stability

December 7, 2022mRNA Therapy ResearchmRNA Deliverycblmrna

Lung-related diseases, including viral infections, tumors, and hereditary diseases, pose a great threat to human life and health. However, the cure for these diseases is still limited. With the development of variousRead More…

27Oct/22

New Potential mRNA Therapy for Chronic Hepatitis B

October 27, 2022mRNA Therapy NewsmRNA LNPs, mRNA Technologycblmrna

Hepatitis B is the most common serious liver disease caused by hepatitis B virus (HBV) infection. Most adults infected with HBV have little or no symptoms and can rely on the immuneRead More…

10Oct/22

BioNTech’s CAR-T + CARVa Therapy has Reduced Clinical Effects on Solid Tumors But Remarkable Effects on Testicular Cancer

October 10, 2022mRNA Therapy News, mRNA Therapy ResearchCAR-T Therapy, CARVa Therapy, mRNA Vaccinescblmrna

At the 2022 annual meeting of the American Association for Cancer Research (AACR), BioNTech released its phase 1 clinical data of CAR-T + CARVac in the treatment of Claudin6 (CLDN6) positive solidRead More…

14Sep/22

Studies Revealed the Vital Function of m6A Modification in T Cells

September 14, 2022mRNA Therapy Researchm6A Modification, mRNA Modificationcblmrna

T cell antigen receptor (TCR) signals can help control the development, activation, and survival of T cells by involving multiple layers and mechanisms regulated by a variety of genes. M6-methyladenosine (m6A) isRead More…

31Jul/22

New insight! Research Progress of mRNA Replacement Therapy for Phenylketonuria

July 31, 2022mRNA Therapy ResearchmRNA therapy, PKUcblmrna

Phenylketonuria (PKU) is an autosomal recessive disease caused by the abnormal metabolism of phenylalanine (Phe). PKU is caused by a mutation in the phenylalanine hydroxylase (PAH) gene. This gene produces a liverRead More…