06Oct/23

Using mRNA Delivery-Based Gene Editing Technology Brings New Hope for Hematological Disorders

October 6, 2023mRNA Therapy ResearchmRNA Delivery-Based Gene Editing, mRNA therapycblmrna

In a recent study, researchers from the Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania developed a proof-of-concept model for delivering gene-editing tools to treatRead More…

06Oct/23

Nature Reviews: mRNA-based Cancer Therapies Could Potentially Change the Future of Cancer Treatment!

October 6, 2023mRNA Therapy ResearchmRNA Technology, mRNA-based Cancer Therapiescblmrna

mRNA-based cancer therapies hold immense potential to revolutionize cancer treatment. However, there are several challenges that need to be addressed for the clinical use of mRNA in cancer therapy. mRNA itself isRead More…

01Sep/23

Optimization Strategy of COVID-19 mRNA Vaccine

September 1, 2023mRNA Therapy ResearchmRNA vaccinecblmrna

Proteins in organisms are primarily composed of 20 common amino acids encoded by 61 codons. Except for methionine and tryptophan, the other amino acids are encoded by 2 to 6 different codons.Read More…

01Sep/23

Nature: Review on the Regulation and Function of Non-M6A Modification on mRNA

September 1, 2023mRNA Therapy Reviewsm6A Modification, RNA Modificationscblmrna

So far, over 170 types of RNA modifications have been identified, and these modifications are widely distributed in non-coding RNAs. With the advancement of detection techniques, various chemical modifications have been detectedRead More…

31Jul/23

PNAS: Novel RNA Nanoparticle Therapy may Block the Spread of Human Mmultiple Myeloma

July 31, 2023mRNA Therapy ReviewsRNA Nanoparticle Therapycblmrna

Multiple myeloma is an incurable bone marrow cancer that causes over 100,000 deaths annually. Known for its rapid and deadly spread, it is one of the most challenging diseases scientists face today.Read More…

02Jul/23

Sanofi Collaborates with MIT to Develop Next-Generation mRNA Delivery Technology

July 2, 2023mRNA Therapy NewsLipid Nanoparticles, mRNA Delivery, mRNA Vaccinescblmrna

International pharmaceutical giant Sanofi recently announced a $25 million investment over five years in MIT’s Daniel Anderson lab to support the development of next-generation mRNA delivery technology. The funding will be utilizedRead More…

04Jun/23

Disassembly of mRNA Vaccine Preparation Process

June 4, 2023mRNA Therapy ReviewsmRNA vaccinecblmrna

The mRNA vaccine, which is rated as an epoch-making innovation. Instead of injecting inactivated or inactivated viruses into the body, this method employs synthetic genetic fragments to emulate viral attacks and stimulateRead More…

08May/23

Predicting mRNA Degradation by AI models to Improve the Stability of mRNA Vaccines

May 8, 2023mRNA Therapy ResearchAI Predicting, mRNA Vaccinescblmrna

The mRNA COVID-19 vaccine plays a key role in the fight against COVID-19. Because of its rapid production ability and promising results in a number of clinical studies, vaccines and treatments basedRead More…

10Apr/23

One of the Most Popular areas of Small Nucleic Acid Research: siRNA

April 10, 2023mRNA Therapy ReviewsmRNA, siRNAcblmrna

Small nucleic acid drugs are short in length and have fewer than 30nt bases. They mainly act on intracellular mRNA through the principle of base complementary pairing to regulate protein expression soRead More…

02Mar/23

Manganese-Based LNP-mRNA Vaccine Has Strong Immunogenicity

March 2, 2023mRNA Therapy ResearchLNP-mRNA Vaccine, mRNA Deliverycblmrna

A variety of vaccines have been approved to prevent COVID-19, including two mRNA vaccines, Comirnty (BNT162b2) developed by Pfizer / BioNTech and Spikevax (mRNA-1273) developed by Moderna. The mRNA vaccine has playedRead More…