As the mRNA vaccine has achieved great results in the prevention of COVID-19, it has been widely recognized by global researchers. At the same time, the application prospect of mRNA technology inRead More…
19May/22
22Apr/22
Great Progress: Novel mRNA Tumor Vaccines Using Bacterial Outer Membrane Vesicles as Delivery Carriers
Therapeutic mRNA vaccines have developed rapidly in recent years, and they have attracted wide attention as a new choice for tumor treatment. Through precise sequence design, mRNA vaccines can encode one orRead More…
11Apr/22
Research Review on Nucleic Acid Drug
Introduction to Nucleic Acid Drugs Nucleic acid is the general name of DNA and RNA, in which DNA is the basis for storing, copying, and transmitting genetic information, while RNA plays anRead More…
11Apr/22
Comparison of Two mRNA COVID-19 Vaccines Approved by the FDA
mRNA (messenger RNA), transcribed from a chain of genetic material DNA, is a chain structure molecule containing four bases (A, U, G, and C). If the mRNA encoding the S protein ofRead More…
28Feb/22
Farewell Needle Injection: Oral Capsule mRNA Vaccine is Coming
Like most vaccines, mRNA vaccines need to be injected with syringes, which can be an obstacle for people who are afraid of needles. If the mRNA vaccine can be delivered orally, itRead More…
18Jan/22
PNAS: Progress in the Mechanism of Organ Selective mRNA Delivery System
In recent years, as a new pharmaceutical technology, mRNA has made a breakthrough in the field of infectious diseases and tumor treatment in a short time. However, how to deliver mRNA drugsRead More…
23Dec/21
Released! A new mechanism of mRNA inactivation in lipid nanoparticles drug delivery system
In response to the SARS-CoV-2 pandemic, mRNA vaccines prepared with lipid nanoparticles (LNPs) have been rapidly developed and deployed. Because of the unstable nature of mRNA, the identification of impurities that mayRead More…
16Nov/21
Novel mRNA Therapy against Cancer: Improvement of PD-1 Antibody in over 80% Mice with Complete Regression of Tumor
mRNA therapy was first used in tumor therapy by injecting mRNA encoding specific proteins such as cytokines into the tumor to intrigue the immune response. However, it still faces the problems ofRead More…
21Oct/21
Progress! SEND New mRNA Delivery Platform Promoting Gene Therapy Development
In a new study, researchers from the Massachusetts Institute of Technology, the McGovern Institute for Brain Science, the Howard-Hughes Institute of Medicine, and the Broad Institute developed a platform for delivering molecularRead More…
28Sep/21
Sequence Design and Delivery Carrier of mRNA Drugs
The structure of mRNA can be divided into five parts, starting from the 5 ‘end, namely, 5’ cap, 5 ‘non-transcriptional region (UTR), open reading frame encoding antigen, 3’UTR and polyadenine tail. EachRead More…