A variety of vaccines have been approved to prevent COVID-19, including two mRNA vaccines, Comirnty (BNT162b2) developed by Pfizer / BioNTech and Spikevax (mRNA-1273) developed by Moderna. The mRNA vaccine has playedRead More…
An Innovative Inhaled mRNA Therapy Possibly Realizes Precise Delivery of mRNA to Lungs
Nucleic acid-based drugs are very adaptable and may encode a wide range of therapeutic proteins for treatment, prevention, or vaccine. Currently, the development and improvement of viral vectors such as lentivirus andRead More…
Lancet Review: Delivery and Clinical Progress of mRNA Cancer Vaccine
The COVID-19 pandemic makes the mRNA vaccine become the focus of global researchers. The rapid development of the COVID-19 vaccine benefits from years of research on using mRNA vaccines as a cancerRead More…
For mRNA-LNP Therapeutics Research: Novel FNP Platform Presents Enhanced Stability
Lung-related diseases, including viral infections, tumors, and hereditary diseases, pose a great threat to human life and health. However, the cure for these diseases is still limited. With the development of variousRead More…
New Potential mRNA Therapy for Chronic Hepatitis B
Hepatitis B is the most common serious liver disease caused by hepatitis B virus (HBV) infection. Most adults infected with HBV have little or no symptoms and can rely on the immuneRead More…
BioNTech’s CAR-T + CARVa Therapy has Reduced Clinical Effects on Solid Tumors But Remarkable Effects on Testicular Cancer
At the 2022 annual meeting of the American Association for Cancer Research (AACR), BioNTech released its phase 1 clinical data of CAR-T + CARVac in the treatment of Claudin6 (CLDN6) positive solidRead More…
Studies Revealed the Vital Function of m6A Modification in T Cells
T cell antigen receptor (TCR) signals can help control the development, activation, and survival of T cells by involving multiple layers and mechanisms regulated by a variety of genes. M6-methyladenosine (m6A) isRead More…
New insight! Research Progress of mRNA Replacement Therapy for Phenylketonuria
Phenylketonuria (PKU) is an autosomal recessive disease caused by the abnormal metabolism of phenylalanine (Phe). PKU is caused by a mutation in the phenylalanine hydroxylase (PAH) gene. This gene produces a liverRead More…
Advantages and Potentials of mRNA Therapy
Advantages mRNA has a unique position in gene therapy and protein therapy, combining the advantages of both therapies while circumventing the challenges faced by both. For example, the difficulty of producing multimericRead More…
The Emerging Field—mRNA Technique in Protein & Cellular Immunotherapy
An emerging field of mRNA technology is in vivo encoding immune proteins or immunomodulatory proteins that can be used therapeutically, such as antibodies and cytokines. One of the main challenges of proteinRead More…