A variety of vaccines have been approved to prevent COVID-19, including two mRNA vaccines, Comirnty (BNT162b2) developed by Pfizer / BioNTech and Spikevax (mRNA-1273) developed by Moderna. The mRNA vaccine has playedRead More…
Nucleic acid-based drugs are very adaptable and may encode a wide range of therapeutic proteins for treatment, prevention, or vaccine. Currently, the development and improvement of viral vectors such as lentivirus andRead More…
The COVID-19 pandemic makes the mRNA vaccine become the focus of global researchers. The rapid development of the COVID-19 vaccine benefits from years of research on using mRNA vaccines as a cancerRead More…
Lung-related diseases, including viral infections, tumors, and hereditary diseases, pose a great threat to human life and health. However, the cure for these diseases is still limited. With the development of variousRead More…
At the 2022 annual meeting of the American Association for Cancer Research (AACR), BioNTech released its phase 1 clinical data of CAR-T + CARVac in the treatment of Claudin6 (CLDN6) positive solidRead More…
T cell antigen receptor (TCR) signals can help control the development, activation, and survival of T cells by involving multiple layers and mechanisms regulated by a variety of genes. M6-methyladenosine (m6A) isRead More…
Phenylketonuria (PKU) is an autosomal recessive disease caused by the abnormal metabolism of phenylalanine (Phe). PKU is caused by a mutation in the phenylalanine hydroxylase (PAH) gene. This gene produces a liverRead More…
Advantages mRNA has a unique position in gene therapy and protein therapy, combining the advantages of both therapies while circumventing the challenges faced by both. For example, the difficulty of producing multimericRead More…
An emerging field of mRNA technology is in vivo encoding immune proteins or immunomodulatory proteins that can be used therapeutically, such as antibodies and cytokines. One of the main challenges of proteinRead More…
As the mRNA vaccine has achieved great results in the prevention of COVID-19, it has been widely recognized by global researchers. At the same time, the application prospect of mRNA technology inRead More…