Growth Factor Receptor mRNA

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Introduction Product List Product FeaturesApplication Q&A

Introduction

Growth factor receptors are proteins on cell membranes that bind specifically to growth factors with high affinity and are associated with regulation of life activities such as cell growth, development, metabolism and aging. In general, high expression of growth factor receptors leads to unlimited cell proliferation, which may be relevant to tumorigenesis. Creative Biolabs offers a range of growth factor receptor mRNA products, including vascular endothelial growth factor receptors (VEGFR, FLK, FLT, KDR), platelet-derived growth factor receptors (PEGFR, GARP), and CD-series growth factor receptors (CD105, CD117, CD140b CD271, CD32). Growth factor receptor mRNA can be mainly used in the study of growth factor mechanism, the exploration of cancer generation mechanism and the development of growth factor-related gene therapy drugs. Creative Biolabs' growth factor receptor mRNA products offer full characterization of synthesis and purification processes to ensure high quality and purity. For each class of product, we also offer a selection of nucleosides with modified moieties (Pseudo-UTP, N1-Methylpseudo-UTP, 5-Methoxy-UTP, etc.).

In addition, Creative Biolabs offers customization services based on the IVTScrip™ platform, capable of producing more diverse and unique growth factor receptor mRNA products, which is an efficient and cost-effective approach. According to customers' experimental objectives, our team can provide a customized solution for synthesis templates, optimization of synthesis ideas and selection of growth factor receptor mRNA modifications in the shortest possible time. The entire customization process follows strict QC standards to ensure high quality mRNA products. Creative Biolabs is always committed to providing you with the highest standard of service and the most competitively priced products. If you are interested in our products, please feel free to contact us.

Product List

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Product Features

Strict Quality Control Standards
- Multiple quality control standards.
- High stability and batch-to-batch consistency.
- Excellent purity and stability profile.
Efficient and Time-saving
- Pre-designed capping and poly (A) tail modification.
- Shorter turnaround time.

Application

Cancer Therapy: Many cancers are driven by mutations in growth factor receptors that lead to uncontrolled cell proliferation. By targeting the mRNA of these receptors, therapies can potentially downregulate their expression, inhibiting tumor growth. For instance, antisense oligonucleotides or siRNAs can be designed to specifically degrade mRNA of mutant growth factor receptors.
Tissue Engineering and Regenerative Medicine: Growth factor receptors are key in mediating cell growth, differentiation, and survival. By manipulating the mRNA levels of these receptors in stem cells or progenitor cells, it is possible to guide the regeneration of specific tissues or organs. This approach can be applied to repair damaged tissues, such as in heart disease, liver disease, or neurological disorders.
Gene Therapy: Techniques involving the delivery of synthetic mRNA that encodes therapeutic growth factors or their receptors can be used to treat various conditions. This method can stimulate healing processes or restore normal function in genetic disorders where a growth factor receptor is deficient or dysfunctional.
Research and Development of Targeted Therapeutics: Understanding the expression patterns and functional implications of growth factor receptors mRNA in diseases allows for the development of targeted therapeutics. For example, blocking the mRNA of specific growth factor receptors involved in angiogenesis (the formation of new blood vessels) can be a strategy to starve tumors of their blood supply.
Biomarker Discovery: mRNA levels of certain growth factor receptors can serve as biomarkers for the diagnosis or prognosis of diseases. Monitoring these mRNA levels can help in assessing disease progression or the efficacy of a treatment.

Q&A

Q: What is the role of growth factor receptor mRNA in cell signaling and communication?

A: Growth factor receptor mRNAs are crucial for the synthesis of growth factor receptors, which mediate cellular responses to growth factors, facilitating processes like cell growth, differentiation, and survival.

Q: How can mutations in growth factor receptor mRNA affect disease progression?

A: Mutations can lead to the production of abnormal receptors, potentially causing uncontrolled cell growth or impaired cell function, contributing to diseases like cancer.

Q: What techniques are used to measure the expression levels of growth factor receptor mRNA in tissues?

A: Techniques include quantitative PCR (qPCR), reverse transcription PCR (RT-PCR), and RNA sequencing (RNA-Seq), which quantify mRNA levels and provide insights into gene expression.

Q: How do growth factor receptor mRNAs contribute to the development of targeted cancer therapies?

A: Understanding the specific mRNAs expressed in cancer cells allows for the development of therapies that target these molecules or their receptors, potentially inhibiting tumor growth.

Q: Can growth factor receptor mRNA levels serve as biomarkers for certain diseases?

A: Yes, the expression levels of certain growth factor receptor mRNAs can serve as biomarkers for diagnosing or monitoring the progression of diseases like cancer. In cancer monitoring, GFRs serve as important biomarkers and therapeutic targets. Their expression levels can indicate the presence and stage of the tumor, as well as predict patient outcome. Furthermore, they can be targeted by cancer therapies to inhibit tumor growth. For example; tyrosine kinase inhibitors (TKIs) and monoclonal antibodies can block the function of GFRs, thereby suppressing tumor growth.

Q: What challenges exist in targeting growth factor receptor mRNA for disease treatment?

A: Challenges include delivering therapeutic molecules specifically to diseased cells without affecting healthy cells, and overcoming mechanisms of drug resistance.

IVTScrip™ mRNA-Human PDGFR, (Cap 0, Pseudo-UTP, 120 nt-poly(A)) (CAT#: GTTS-WK0035MR)

Product type mRNA

Transcript PDGFR

Category (CDS) Growth Factor Receptor

Applications Gene therapy research