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Custom mRNA Synthesis

Signal Transduction mRNA

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Introduction Product List Product FeaturesApplication Q&A

Introduction

Signal transduction molecules interact to convert and transmit signals constituting various signal transduction pathways. Cells can respond to environment with relevant effects through signalling pathways, ultimately regulating specific gene expression, metabolism and apoptotic processes. The signalling process involves a range of important functional proteins, including extracellular signalling molecules (such as hormones), membrane proteins, receptors and enzymes. When any part involved goes wrong, the body is likely to develop related diseases. Creative Biolabs offers a wide range of signal transduction mRNA products carefully designed and optimised by an established and dedicated team of experts to encode the most common signal transduction proteins such as synaptophysin, SOST, Go-alpha, and CD series. We also provide you with nucleoside modification options (e.g. Pseudo-UTP, N1-Methylpseudo-UTP), so that you can choose appropriate product according to your experimental project. Signal transduction mRNA products are mainly used in the study of signal transduction pathway mechanism, related disease mechanism investigation and gene therapy method research.

For the flexibility of our IVTScrip™ synthesis platform, our experts can also provide additional customisation options according to your project requirements within a very short delivery time. The customisation service for signal transduction mRNA products focuses on strand length, nucleoside modification type, poly(A) length and 5' cap end optimisation. We also ensure that the entire process is strictly QC compliant, with purification results and mass spectrometry characterisation provided at each step. If you are interested in our products, please feel free to contact us.

Product List

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Product Features

  • Strict Quality Control Standards
    • Multiple quality control standards.
    • High stability and batch-to-batch consistency.
    • Excellent purity and stability profile.
  • Efficient and Time-saving
    • Pre-designed capping and poly (A) tail modification.
    • Shorter turnaround time.

Application

  • Cancer Research: In the realm of cancer research, signal transduction mRNA plays a pivotal role in understanding how alterations in signaling pathways contribute to tumorigenesis, tumor growth, and metastasis. As an example, research has shown that the expression levels of Receptor Tyrosine Kinases (RTKs) mRNA are upregulated in various types of cancer, resulting in the overactivation of cell proliferation signals. By utilizing quantitative PCR techniques to measure the expression levels of specific RTK mRNA in tumor tissue samples, researchers can identify potential targets for cancer treatment.
  • Disease Diagnosis: Signal transduction mRNA is instrumental in developing diagnostic markers for early disease detection. As an example, in cardiac disease research, it has been found that myocardial cells change the mRNA expression of certain signaling molecules, such as cAMP-response element-binding protein (CREB), when they are damaged. By analyzing the level of CREB mRNA in blood samples, it can serve as an early marker for cardiac attacks.
  • Drug Development: In drug development, targeting the mRNA of signal transduction molecules offers a strategy for identifying new therapeutic agents. For example, studies on the PI3K/Akt signaling pathway, implicated in cancer cell survival and growth, involved screening compounds that could downregulate Akt mRNA expression in cancer cell lines. Through high-throughput screening and subsequent mRNA level quantification via qPCR, researchers identified novel small-molecule inhibitors of Akt. This exemplifies how manipulating signal transduction mRNA can aid in discovering new drugs with potential cancer therapy applications.
  • Immune Regulation: Signal transduction mRNA is crucial for regulating the immune response, including T cell activation and differentiation. For example, a notable study focused on the T cell receptor (TCR) signaling pathway, specifically analyzing ZAP-70 mRNA expression, a kinase critical for T cell signaling. By quantifying ZAP-70 mRNA levels in T cells from patients with autoimmune diseases versus healthy controls, researchers could link aberrant ZAP-70 expression to autoimmune pathogenesis to better understand the significance of signal transduction mRNA in modulating immune responses.
  • Cell Death and Survival Research: The study of cell death and survival heavily relies on understanding the mRNA expression of signal transduction molecules involved in apoptotic pathways. For example, research into the mRNA levels of Bcl-2 family members, which regulate the intrinsic apoptosis pathway, has provided insights into the mechanisms of programmed cell death. One study employed RT-PCR to measure the mRNA levels of pro-apoptotic (e.g., Bax) and anti-apoptotic (e.g., Bcl-2) genes in response to chemotherapeutic agents in cancer cells. The balance between these mRNA levels determines the cells' fate, highlighting how signal transduction mRNA research contributes to our understanding of cell survival mechanisms and the development of more effective cancer treatments.

Q&A

Q1: How does Creative Biolabs ensure the quality and customization of signal transduction mRNA products?

A: Creative Biolabs offers customization options for signal transduction mRNA products, including strand length, nucleoside modification type, poly(A) length, and 5' cap end optimization, with strict QC compliance and detailed characterization at every step.

Q2: How do signal transduction pathways involving mRNA impact gene expression, metabolism, and apoptotic processes?

A: Signal transduction pathways, facilitated by mRNA for proteins like synaptophysin and CD series, play a critical role in cellular responses to environmental stimuli, impacting gene expression, metabolism, and apoptosis.

Q3: What are the customization options for signal transduction mRNA products, and how do they affect research outcomes?

A: Customization options for signal transduction mRNA products include strand length, nucleoside modification type, poly(A) length, and 5' cap end optimization. These variations can significantly influence the outcomes of gene therapy research and the study of signal transduction pathway mechanisms.

Q4: What are the primary applications of signal transduction mRNA in current research?

A: Signal transduction mRNA products are predominantly utilized in studying the mechanisms of signal transduction pathways, investigating the mechanisms behind related diseases, and researching gene therapy methods.

Q5: What roles do signal transduction mRNAs play in cellular communication and disease progression?

A: Signal transduction mRNAs are crucial for transmitting signals within cells to ensure proper cellular function. They are deeply involved in processes related to disease development and progression.

Q6: How can modifications to signal transduction mRNA influence therapeutic outcomes?

A: Modifications to mRNA, such as nucleoside changes, can significantly affect its stability, translation efficiency, and immune response, thereby influencing therapeutic outcomes.

Q7: How to solve the problem of specificity of signal transduction mRNA products in the experiment?

A: Creative Biolabs solves specificity issues in signal transduction mRNA experiments by tailoring mRNA designs for specific signaling pathways, ensuring targeted gene expression with high specificity.

Q8: How to overcome the RNA degradation problem in the sample preparation while studying signal transduction mRNA products?

A: To address RNA degradation, Creative Biolabs implement advanced mRNA modification strategies, including incorporating modified nucleosides that enhance RNA stability during sample preparation and experiments.

Q9: How to ensure the repeatability of experimental results of signal transduction mRNA products?

A: For repeatability, Creative Biolabs emphasizes strict quality control measures, including meticulous synthesis processes and thorough validation steps, to ensure consistent and reliable signal transduction mRNA product quality across experiments.

Product type mRNA
Transcript Synaptophysin
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript NOV
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CYR61
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript SOST
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript RUNX2
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript Go-alpha
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD147
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD59
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript D105
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD9
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CTNNB1
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript MCAM
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript TNC
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript VWF
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript FZ4
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript WNT4
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD24
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD34
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript GCET2
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript HGAL
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD133
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD71
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD63
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript FSHR
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript FBLN5
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript GPR44
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript TM4SF1
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript Synaptophysin
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript NOV
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CYR61
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript SOST
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript RUNX2
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript Go-alpha
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD147
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD59
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript D105
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD9
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CTNNB1
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript MCAM
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript TNC
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD24
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD34
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript GCET2
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript HGAL
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD133
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD71
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD63
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript FSHR
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD147
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD59
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript D105
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD9
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CTNNB1
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD24
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript CD34
Category (CDS) Signal Transduction
Applications Gene therapy research
Product type mRNA
Transcript GCET2
Category (CDS) Signal Transduction
Applications Gene therapy research