Transporter mRNA

Introduction

Transporter proteins are a large group of membrane proteins that mediate the exchange of chemicals inside and outside biological membranes, playing an important role in a wide range of cellular activities such as nutrient uptake, metabolite release and signal transduction. Creative Biolabs offers mRNA products encoding various types of transporter proteins such as aquaporin-0, chlorine channel protein (CLCC1), potassium channel protein (KCNQ4), and secretory carrier membrane protein (SCAMP3). The various types of transporter mRNA products offered by Creative Biolabs are synthesised on unique IVTScrip™ platform, which is a convenient and cost-effective way to produce long-stranded mRNA. We provide transporter mRNAs for post-translational studies on the function and mechanism of the corresponding transporter proteins, providing new ideas for transporter protein-related disease research and gene therapy approaches.

In addition to a range of pre-products, we also aim to offer a variety of long-stranded, customised products of transporter mRNA with different purification options and modification strategies. You can provide the DNA template directly and we will be responsible for optimising the synthesis route. Alternatively, we can provide you with a one-stop shop for customisation of transporter mRNA starting with template construction. Based on the flexibility and scalability of the IVTScrip™ platform, our experts with extensive experience in mRNA synthesis can choose from many additional customisation options to suit your project needs. Our customisation service is extremely cost effective as we have more affordable prices and shorter turnaround time. If you are interested in our products, please feel free to contact us.

Product List

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Product Features

• Strict Quality Control Standards
  • Multiple quality control standards.
  • High stability and batch-to-batch consistency.
  • Excellent purity and stability profile.
• Efficient and Time-saving
  • Pre-designed capping and poly (A) tail modification.
  • Shorter turnaround time.

Application

• Physiological Adaptation Studies: Transporters help organisms adapt to environmental changes, such as variations in salinity or pH, by regulating the movement of ions and molecules across cell membranes. For example, by analyzing the expression of transporter protein genes at the transcriptional level, such as Na+/K+-ATPase, Na+/K+/2Cl- cotransporter, and V-type H+-ATPase, researchers are able to reveal how organisms adapt to changes in environmental salinity by regulating the expression of these transporter proteins.
• Cancer Treatment: In cancer, transporter mRNAs such as ZIP13 and SLC7A5 are involved in tumor progression and metastasis. They can influence survival outcomes and serve as potential biomarkers for prognosis and therapeutic targets. For example, a study on ovarian cancer demonstrated that the zinc transporter ZIP13 facilitated metastasis via the Src/FAK signaling pathway. Knockout of ZIP13 in ovarian cancer cell lines significantly reduced peritoneal dissemination in vivo, underscoring its role in tumor metastasis and indicating its potential as a therapeutic target.
• Gene therapy and protein replacement therapy: Transporter mRNA in gene therapy and protein replacement therapy is pivotal for treating diseases by facilitating the production of therapeutic proteins within the body. Notable applications include Moderna's mRNA-3927 for Propionic Acidemia, showing promising early clinical results with significant risk reduction in life-threatening events and highlighting mRNA's potential in addressing the root cause of diseases.
• Research tools: Transporter mRNA can also serve as a research tool, helping scientists study how cells regulate the influx and efflux of substances. By studying specific transporter mRNA, we can better understand how cells respond to environmental changes, how they transmit signals, and how they maintain internal stability. These studies are significant in revealing the basic principles of cellular physiology.

Q&A