Cell Adhesion Molecule mRNA

Introduction

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface that bind to other cells or the extracellular matrix during cell adhesion. Cell adhesion molecules play an important role in maintaining tissue structure, influencing cell growth, contact inhibition and apoptosis mechanisms. Creative Biolabs has a well-designed range of mRNA products for cell adhesion molecules under different modification strategies. When selecting the cell adhesion molecule mRNA product, you can first identify the type of adhesion molecule (CEACAM1, ICAM1, KIAA1114, EpCAM,etc.) and then select the appropriate nucleoside modification group type (Pseudo-UTP, N1-Methylpseudo-UTP, etc.) according to your project needs. Based on advanced IVTScrip™ synthesis platform, Creative Biolabs offers cell adhesion molecule mRNA products that are used primarily to study the physiological mechanisms of different cell adhesion molecules, as well as cell biology and gene therapy research.

Given the diversity of cell adhesion molecule types and modifiable strategies, Creative Biolabs' experts provide you with customizable cell adhesion molecule mRNA design services. At Creative Biolabs, all customized services have to be carried out under the rigorous QC process, with each step accompanied by large-scale purification and mass spectrometry characterization to ensure the purity and quality of the final synthesised cell adhesion molecule mRNA product. In addition to designing templates anew, you can also choose existing DNA templates directly and we will mainly provide you with subsequent synthesis line optimization solutions with shorter delivery time. If you are interested in our products, please feel free to contact us.

Product List

>>>Can't find what your looking for? Contact us and we will be happy to help.

Product Features

• Strict Quality Control Standards
  • Multiple quality control standards.
  • High stability and batch-to-batch consistency.
  • Excellent purity and stability profile.
• Efficient and Time-saving
  • Pre-designed capping and poly (A) tail modification.
  • Shorter turnaround time.

Application

• Cancer Research: In cancer research, the expression levels of cell adhesion molecule (CAM) mRNAs are closely linked to tumor progression, metastasis, and patient prognosis. For example, a significant body of research focuses on E-cadherin (CDH1) mRNA, as its downregulation is often associated with increased invasiveness and metastasis in carcinomas. Some experiments have employed quantitative PCR to measure CDH1 mRNA levels in tumor samples, correlating these levels with clinical outcomes to provide insights into the mechanisms underlying cancer metastasis.
• Immunology Research: CAM mRNA plays a pivotal role in immunology, especially in the context of leukocyte migration and activation. The intercellular adhesion molecule 1 (ICAM-1) mRNA is of particular interest due to its role in leukocyte endothelial transmigration. Experimental studies often focus on the regulation of ICAM-1 mRNA expression under inflammatory conditions to elucidate the molecular mechanisms governing immune cell trafficking and offer potential targets for controlling inflammatory responses.
• Neuroscience: In neuroscience, CAM mRNAs are fundamental to understanding the molecular basis of neuron-neuron and neuron-glia interactions, which are critical for brain development and function. An example of such research involves the neural cell adhesion molecule (NCAM) mRNA, where studies have investigated its role in synaptic plasticity. Experimental approaches have included using in situ hybridization to map NCAM mRNA distribution in the brain, associating its expression patterns with processes such as learning and memory. These findings contribute to our understanding of the molecular underpinnings of neural plasticity and neurological disorders.
• Drug Development: In the realm of drug development, targeting the mRNA expression of CAMs offers a novel therapeutic strategy. For instance, antisense oligonucleotides (ASOs) designed to knock down the mRNA of specific CAMs, such as Vascular Cell Adhesion Molecule 1 (VCAM-1), have been explored for their potential to treat inflammatory diseases. These ASOs can specifically bind to the VCAM-1 mRNA, blocking its translation and thereby reducing endothelial cell inflammation and leukocyte adhesion. This approach exemplifies how understanding and manipulating CAM mRNA expression can lead to the development of new drugs.
• Stem Cell Research: CAM mRNAs are crucial for the maintenance of the stem cell niche and the regulation of stem cell behavior. Research in this area often focuses on the role of CAMs in mediating interactions between stem cells and their microenvironment. A notable study involved examining the mRNA expression of N-cadherin in mesenchymal stem cells (MSCs), demonstrating its importance in maintaining stem cell pluripotency. Experimental techniques such as RNA sequencing were used to assess the impact of N-cadherin knockdown on MSC differentiation, revealing that N-cadherin supports the stemness of MSCs by modulating cell-cell interactions within the stem cell niche.

Q&A