RBP mRNA Products

Introduction

RNA binding proteins (RBPs) play an important role in the regulation of post-transcriptional gene expression by interacting with RNA to regulate cellular function. RBPs are mainly involved in RNA splicing, polyadenylation, sequence editing, RNA translocation, intracellular localisation, translational control, maintenance of mRNA stability and degradation. Creative Biolabs offers a range of highly efficient translational and long-stranded mRNA products that can encode RBPs for applications in the study on the mechanisms of interaction between RBPs and RNAs, as well as RBPs-related gene therapy drugs. All RBPs mRNA products are synthesised on the advanced IVTScrip™ platform, which is the most convenient and least costly method for synthesising long-stranded mRNA. The RBPs that can be encoded from the mRNA products we provide include PIWIL1, PUM2, and LIN28B. Furthermore, you can choose the most suitable modification options according to your needs, such as 5'-Capping (e.g. Cap0, Cap1), 3'-tailing (e.g. 30 nt-polyA, 120 nt-polyA), and nucleoside modifier groups (e.g. Pseudo-UTP, N1-Methylpseudo-UTP).

If you can not find the right RBPs mRNA in the pre-product list, our experienced team of experts can also give you professional RBPs mRNA customisation service to meet your specific project requirements. The custom RBPs mRNA synthesis process follows the same QC standards as the pre-production, with services including template design, route optimisation, modification strategy selection, multi-step product purification and product mass spectrometry characterisation. Our comprehensive and high level one-stop customisation service will allow you to experience shorter turnaround time and more affordable prices. If you are interested in our products, please feel free to contact us.

Product List

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Product Features

• Strict Quality Control Standards
  • Multiple quality control standards.
  • High stability and batch-to-batch consistency.
  • Excellent purity and stability profile.
• Efficient and Time-saving
  • Pre-designed capping and poly (A) tail modification.
  • Shorter turnaround time.

Application

• Gene Expression Regulation: RBPs exert regulatory functions at multiple stages of gene expression by binding with mRNA, influencing its stability, transport, splicing, and translation. For example, RBPs are capable of recognizing and binding to unstable elements in mRNA, thereby promoting its degradation or stability. Furthermore, RBPs can also participate in the regulation of selective splicing, by selectively binding to specific splicing sites, affecting the assembly of spliceosomes and the progression of splicing reactions. These functions make RBPs an important tool in studying the complexity of gene expression and regulatory mechanisms.
• Disease Mechanism Studies: RBPs play significant roles in the development and progression of various diseases, including neurodegenerative diseases, cancer, and cardiovascular diseases, among others. For instance, TDP-43 and FUS are two RBPs closely associated with Amyotrophic Lateral Sclerosis (ALS), their abnormal aggregation in ALS patients is related to the disease's progression. By studying the functions of these RBPs and their abnormal changes in diseases, the molecular mechanisms of diseases can be revealed, providing new strategies for disease diagnosis and treatment.
• Drug Development: Small molecule inhibitors or activators targeting RBPs could serve as potential drugs for the treatment of various diseases. For example, specific small molecule drugs could be developed to regulate the activity of certain RBPs with abnormal expression in cancer, thereby inhibiting tumor growth. Furthermore, by studying the interface of interactions between RBPs and RNA, highly specific molecules could be designed to disrupt these interactions, providing new therapeutic approaches for diseases caused by abnormalities in RNA metabolism.
• Bioinformatics and Systems Biology: With the development of high-throughput sequencing technology, the applications of bioinformatics and systems biology in RBP (RNA Binding Proteins) research are increasingly numerous. By integrating vast amounts of data generated by technologies such as RNA-Seq and CLIP-Seq, researchers can identify RBP binding sites at the whole genome level, analyze RBP binding patterns, and their functions in different biological processes. This information helps to reveal the mechanisms of RBPs in complex biological processes, providing important clues for disease research and treatment.
• Immunology Research: RBPs play significant roles in immune system regulation by controlling the expression of cytokines, chemokines, and other immune response genes at the post-transcriptional level. The RBP Regnase-1 is known to degrade mRNAs encoding inflammatory cytokines, thereby preventing excessive inflammation. Research has demonstrated that Regnase-1-deficient mice exhibit uncontrolled inflammation due to increased stability of mRNAs encoding inflammatory mediators, illustrating the critical role of RBPs in maintaining immune homeostasis.

Q&A