As a well-established company in the bio-industry, Creative Biolabs offers the best glyceryl palmitostearate-based lipids development services. Guaranteed to perform within the specified time frame and the quality of your project is always maintained to the end. Our laboratory services have many advanced chemical and biological technologies to support customer's needs in the fast-growing mRNA delivery system research.
Glyceryl palmitostearate is a mixture of glycerol, palmitic acid, mono- or di-stearic acid, and triglyceride. It is a kind of weak acid organic compound of long-chain fatty acid. Fatty acids typically contain between 13 and 21 carbon atoms at the end. It is produced by the esterification of glycerol and palmitic acid in the presence of a catalyst. It is in the form of colorless needle crystal, soluble in hot alcohol, ether, and oxy form but insoluble in alcohol or water.
In the past few years of studies, glycerol palmitostearate has been considered as a main solid-lipid nanoparticle and widely used for mRNA delivery. Glyceryl palmitostearate is usually used as the matrix of a new mRNA delivery system to wrap candidate drugs in lipid nuclei and produce solid lipid particles with a particle size of about 50-1000nm. The data have demonstrated that glyceryl palmitostearate has the advantages of polymer nano or micron particles, which do not undergo chemical degradation and are easier to adjust the release of the compound.
Fig.1 Schematic presentation of the complete structure of solid lipid nanoparticles with advantages over liposomes and lipid emulsion. (Tekade, 2017)
Currently, glyceryl palmitostearate, as a major component of solid lipid nanoparticles, has attracted extensive attention and research. Pilot studies have shown that glyceryl palmitostearate has good physiological compatibility and tolerance, which plays an important role in determining the particle size of solid lipid particles. By continuing to grow in response to the requirements of our clients, Creative Biolabs is dedicated to harnessing the unique properties of glyceryl palmitostearate to improve the performance of various mRNA delivery systems. Our exclusive surface modification, physical, and chemical properties analysis protocols can selectively generate and modify glyceryl palmitostearate suitable for different mRNA delivery types. For instance, a wide range of solid lipid particles based on glyceryl palmitostearate have been established by our labs to develop mRNA delivery systems with strong targeting, a high encapsulation rate, and good cell affinity.
As a leader in the field of mRNA studies, Creative Biolabs has built a team of experienced scientists with facilities and processes designed specifically to provide the best-customized services to help you design and evaluate the safety and efficacy of your mRNA delivery projects. We have established an advanced glyceryl palmitostearate research platform that enables us to help build and establish a long-term vision with commercialization in mind. If you are interested in our services, please contact us or send us an inquiry.
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