Glyceryl Monostearate

Creative Biolabs is one of the well-recognized experts in supporting a broad range of mRNA projects. With over a decade of extensive experience in mRNA delivery, our scientists are proud to offer the best-fit reagents to meet your specific mRNA delivery requirements.

Composition of Solid Lipid Nanoparticles (SLNs)

SLNs are colloidal particles composed of solid lipids. They have become a group of desired delivery systems due to their excellent biocompatibility. Solid lipids utilized in SLN formulations include fatty acids, triglycerides, steroids, partial glycerides, and waxes. Among them, stearic acid-based SLNs have been explored as an effective means of drug delivery and found to be a sound basis for reducing dosing frequency and improving patient compliance.

GMS-based Stable SLNs for mRNA Delivery

SLNs are aqueous colloidal dispersions produced in solution using (in part) solid lipidic material, which comprises the so-called lipid matrix, and surfactants and cosurfactants, which confer stability and ligand properties to the formulation, respectively. Depending on the procedure of preparing, the particles obtained are usually in the submicron range (10-1000 nm). Glyceryl monostearate (GMS), a glycerol ester of stearic acid, occurs naturally in the body as a by-product of the breakdown of fats. In recent years, many laboratories used GMS as the lipid matrix to encapsulate mRNA drugs.

Hydrophobic modification of the carrier, such as GMS, is an effective way to increase the absorption of molecules. Researchers recently reported that the SLNs prepared with GMS had a high loaded capacity and good stability. GMS can be selected as the hydrophobic part since its fatty acid chains can interact with the phospholipid component of the membrane, thereby leading to increased permeability. It is assumed that increasing the lipophilicity of chitosan-based nanocarrier by GMS modification may be an effective way to enhance the peroral absorption of drugs, and the absorption extent might be modification degree dependent. In addition, nanoparticles prepared with GMS allow more molecules to be released at the same time points tested.

Fig.1 The preparation of drug-loaded SLNs. (He, 2019)

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Reference

1. He, J.; et al. Carvacrol loaded solid lipid nanoparticles of propylene glycol monopalmitate and glyceryl monostearate: preparation, characterization, and synergistic antimicrobial activity. Nanomaterials. 2019, 9(8), 1162.