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Creative Biolabs is one of the well-recognized experts who are professionals in the field of mRNA delivery. Now, we are proud to offer a series of reagents for mRNA delivery, such as monoglycerides (glyceryl monostearate, glyceryl hydroxy stearate, and glyceryl behenate).

mRNA-based drugs are becoming an important class of therapeutic agents due to their role in physiology and the rapid advances in biotechnology and genetic engineering. Therefore, efficient drug delivery systems are necessary to deliver these RNAs to achieve the desired therapeutic action. Monoglyceride-based delivery systems for the control of emulsion and foam stability are exciting systems for this field. This application is based on the potential of monoglycerides to adsorb at interfaces, crystallize, and co-crystallize.

Monoglyceride Self-assembly Structures Used for Drug Delivery

Monoglycerides are non-toxic, biocompatible, and biodegradable and show good chemical and physical stability of incorporated drugs. An intriguing characteristic of monoglycerides is their capacity to form various self-assembly structures, i.e., liquid crystalline phases if contacted with water. The monoglyceride (glycerol monooleate and glycerol monolinoleate) swell upon contact with an aqueous medium by taking up water. During this process, monoglycerides are transformed into various liquid crystalline phases (anisotropic hexagonal and lamellar) and finally into a very viscous (isotropic) cubic phase.

Monoglyceride liquid crystalline phases were prepared as carriers for water-soluble small molecules, nucleic acid, and peptides by incorporating drug solutions into the monoglycerides. The cubic phase of monoglyceride has a thermodynamically stable structure and, due to its amphiphilic nature, can be used as a carrier for both hydrophilic and lipophilic molecules. The molecule release occurred primarily from the cubic phase. This is due to an increase in diffusivity in the monoglyceride matrices and an increased solubility.

SLNs in RNA interference gene therapy.Fig.1 SLNs in RNA interference gene therapy. (Thakor, 2013)

Depending on the capacity to incorporate the potential guest molecules within the various phases in appropriate amounts and to disperse them within a complex matrix without losing the expected functionality, self-assembly structures of the monoglyceride family can be used as delivery systems, including three systems:

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  1. Thakor, A. S.; Gambhir, S. S. Nanooncology: the future of cancer diagnosis and therapy. CA: a cancer journal for clinicians. 2013, 63(6), 395-418.
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