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Creative Biolabs is one of the well-recognized experts who are professional in applying advanced platforms for the development of drug delivery systems. Now we are proud to offer a series of reagents, such as butanol for the formation of the microemulsion.

Introduction of Co-surfactant

Generally, co-surfactants are usually short-chain alcohols or amines ranging from C4 to C10, including butanol, pentanol, ethanol, isopropanol, as well as propylene glycol. There are three kinds of microemulsion which include bicontinuous, oil-in-water, and water-in-oil. Among them, oil-in-water (o/w) microemulsions are more important for oil-soluble drugs delivery. In general, the components of a microemulsion contain oil, surfactant, and co-surfactant. Fine o/w microemulsions can be formed under gentle agitation following dilution by aqueous phases.

Roles of Co-surfactant

  • Increase the flexibility of the surfactant film around the microemulsion droplet.
  • Helps in the formation and stabilization of micelles and microemulsions.
  • Overcome the repulsive forces of similar phases and fluidity of the oil and water.
  • Increase the permeability of the oil and water phases.

Butanol in SLN and NLC

In recent years, Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) have been the novel medicinal carriers to control drug targeting and release in multiple administrations including topical, oral, ophthalmic, and parenteral. These medicinal carriers present a series of advantages, such as improved drug stability, higher drug payload, as well as biosafety. To obtain the warm O/W microemulsion, lipids would be melted at a temperature of 65oC. Then, 1-butanol co-surfactant should be added dropwise until a clear microemulsion was formed to obtain the microemulsion zone. Considering convenience and safety, butanol is the best co-surfactant to produce an excellent performing emulsion.

Schematic diagram showing the effect of chain length of co-surfactant on the reverse micelles in microemulsion.Fig 1. Schematic diagram showing the effect of chain length of co-surfactant on the reverse micelles in microemulsion. (Vaidya, 2019)

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  1. Vaidya, S.; Ganguli, A. Microemulsion methods for synthesis of nanostructured materials. 2019.
For Research Use Only.

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