Nucleotides Modification

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Nucleotides Modification

As a world-leading services provider, Creative Biolabs is dedicated to providing a full range of customized nucleotides modification services for worldwide clients based on the value of time-saving and cost-effective manner.

Overview of Nucleotides Modifications

When it comes to the bio-molecular modifications, the first thing that comes to mind is the post-translational modification of proteins, which has been indicated to exert essential roles in a variety of signaling pathways, cellular activities, and many other biological functions. However, it has been found that post-translational modification is not only the “privilege” of proteins, but also occurs in other biomolecules in the organism, such as DNA and RNA. And post-transcriptional modification of RNA can enhance the stability of RNA structure, improve the efficiency of translation, and increase the structural and functional diversity of RNA.

RNA modification generally refers to the alterations (mainly addition and substitution) of chemical groups on four RNA bases and the ribose sugar moiety, leading to the secondary/tertiary structures and functions change of RNAs. Currently, there are at least 170 types of RNA modifications have been discovered in all living organisms. These modified RNAs are widely distributed in all kinds of RNAs, among which ribosomal RNA (rRNA) and transfer RNA (tRNA) are the most heavily modified. The base type, location, and quantity of the modifications all have an impact on the stability, activity, recognition, localization of RNAs, and they may also be related to some human diseases.

Internal RNA modifications.Fig.1 Internal RNA modifications. (Barbieri, 2020)

Custom Nucleotides Modification Services

Nucleotides modifications affect a diversity of biological processes in the organisms. For instance, modifications (commonly N⁶-methyladenosine) in messenger RNA (mRNA) regulate various aspects, such as mRNA location, metabolism, stability, protein translation, even stem cell differentiation. Chemical modifications in tRNA and rRNA directly affect protein translation. In humans, these diverse modifications in RNAs are closely linked to some human disorders, such as tumors and cancers, neurological disorders, mitochondrial-linked diseases, and diabetes.

All these properties and critical bio-functions endow the RNA modification of great potential to be a useful tool in laboratory analysis and therapeutics development. Firstly, the modified RNAs can be used for the control of gene expression and cell differentiation in epigenetics research, also can be utilized for RNA structure optimization. More importantly, the development of these nucleotides modifications or effective inhibitors holds great potential in human disease treatment.

Creative Biolabs provides a diversity of fully custom mRNA modification services based on the four basic base modifications as follows:

Pseudouridine(Ψ)

5-ribosyl isomer of nucleoside uridine

Pseudouridine

2-Thiouridine (s2U)

C-5 sulf-modified nucleoside uridine

2-Thiouridine

5-Methylcytidine (m5C)

C-5 methyl-modified nucleoside cytidine

5-Methylcytidine

N6-Methyladenosine (m6C)

N-6 methyl-modified nucleoside adenosine

N6-Methyladenosine

Our Highlighted Features

  • Fully customized: both single type modification and one-stop design to detection are all available
  • Well-established platform: equipped with advanced biological techniques and experienced scientist teams
  • Time-saving: rapid in silico prediction and bioinformatics analysis provide assistance
  • High performance: standard experimental procedures, professional staff, and abundant expertise offer the most optimized and tailored solutions

Please directly contact us for more detailed information, we can customize our offering to meet your specific project needs.

Reference

  1. Barbieri, I.; Kouzarides, T. Role of RNA modifications in cancer. Nature Reviews Cancer. 2020, 1-20.
For Research Use Only.

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