mRNA for Regenerative Medicine

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mRNA for Regenerative Medicine

As an expert in the field of messenger ribonucleic acid (mRNA) studies, Creative Biolabs is helping our customers with various mRNA therapeutics services targeting regenerative medicine. Based on our deep analytical capabilities and vast experience in mRNA studies, our client-focused, integrated team will anticipate challenges, overcome difficulties, and provide custom mRNA-based preclinical studies with numerous assays. We guarantee the finest results for our customers all over the world.

Introduction to Regenerative Medicine

Regenerative medicine is a branch of modern medicine that seeks to develop novel methods for replacing, repairing, or healing damaged cells, tissues, and organs. Pilot studies have shown that regenerative medicine has been widely used for treating a wide array of disease conditions, such as progressive disorders, diabetes, as well as arthritis. In general, regenerative medicine is composed of the design and application of stem cells, tissue engineering, immunomodulation therapy, cellular therapies, and the generation of medical devices or artificial organs. Among them, the delivery of therapeutic cells to specific tissues has become a common strategy for regenerative medicine. Till now, different kinds of autologous cells or allogeneic cells have been broadly used for further proliferating in target tissues or organs. Meanwhile, recent researchers have revealed that synthetic mRNAs play an important role in regulating the delivery of functional proteins in regenerative medicine.

Native mRNA structure. Fig.1 Native mRNA structure. (Patel, 2019)

mRNA-based Regenerative Medicine

Regenerative medicine has proven its significant role in regenerating the damaged cells or tissues. A panel of assays, such as tissue engineering and cell-based assays, have been generated for restoring the normal function of cells or tissues. Among them, proteins have been regarded as critical molecules that are essential to regulate cell growth, cell differentiation, cell proliferation, cell metabolism, and cell apoptosis. Many actions have been taken to help the effective delivery of these proteins into loss-of-function sites. However, direct injection of proteins has caused several issues reflecting their low in vivo stability and biological activities. As a consequence, recent studies have indicated that mRNAs are emerging as safe and promising alternatives for proteins that can be transported to the defect sites.

With the commitment of being your best mRNA therapeutics development partner, Creative Biolabs has established the utmost efficient integrated mRNA solutions to innovate and accelerate your development process for many applications, especially for regenerative medicine. Equipped with a team of professional scientists, we have generated a group of mRNA-based systems for our clients to offer mRNA design and synthesis, mRNA modification and purification, mRNA delivery, as well as mRNA-based stem cell engineering. For example, we have developed several efficient mRNA polymeric delivery systems that have been used for the treatment of pulmonary diseases. Besides, we also provide a range of mRNA-based therapeutics optimization services to improve the stability and transmission capacity and reduce the potential immunogenicity of mRNA in clinical use.

Structural features of different sugar and base modifications to enhance translational efficacy of mRNA with reduced immunogenicity. Fig.2 Structural features of different sugar and base modifications to enhance translational efficacy of mRNA with reduced immunogenicity. (Patel, 2019)

Creative Biolabs is dedicated to expanding cutting edge mRNA research across a range of applications. With our proven competencies and regulatory expertise, we are therefore confident in offering the best mRNA services for regenerative medicine. We can provide many flexible options, from which you can always find a better match for your particular project. If you are interested in our services, please feel free to contact us for more information.

Reference

  1. Patel, S.; et al. Messenger RNA Delivery for Tissue Engineering and Regenerative Medicine Applications. Tissue Engineering Part A. 2019, 91-112.
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