Custom Chemical Synthesis of mRNA

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Creative Biolabs is one of the global companies to support our customers' projects. With the latest instruments and professional staff, we are dedicated to offering first-class chemical synthesis mRNA services to meet your specific goal in a time-saving manner.

Chemical Synthesis of mRNA

Modified mRNAs can readily be obtained from any DNA template using RNA polymerases in a short time. However, mRNA prepared with enzymatic synthesis may present transcriptional errors, which can only be produced at a laboratory scale, and products may not pure enough for the intended use. An efficient scalable non-enzymatic (chemical) method for mRNA production could solve these problems. Chemical synthesis of single-stranded mRNA molecules is a widely used laboratory procedure that is an alternative strategy of mRNA synthesis for RNA research as well as RNA biopharmaceuticals. This technique is versatile and allows the researcher to tailor the synthesis of short fragments of mRNA and introduce modifications to mRNA.

Structural mRNA feature.Fig.1 Structural mRNA feature.

Chemical synthesized RNA can be used in the development of mRNA vaccines and genome editing tools, as well as the development of mRNA amplification-based diagnostics. Creative Biolabs normally uses solid-phase synthesis to assemble mRNA strands, which can yield large amounts of modified RNAs that can be further highly purified by conventional methods. According to your research's requirement, we can offer custom chemically-synthesis mRNA services to synthesize the desired mRNA of short length and consistently obtain superior levels of purity. Moreover, we can also provide a wide range of post-transcriptional modifications, various purification options, and an analytical service suite for our customers' specific requirements. Numerous purification options are available at Creative Biolabs to allow high-level purification and quality check of our mRNA. The comprehensive quality control and quality assurance systems ensure a robust manufacturing process, as well as superior and consistent batch-to-batch quality for our customers.

Advantages of Our Services

  • Strong technology support to produce high-quality custom-manufactured mRNA
  • Experienced staff and advanced technologies
  • Guaranteed quantity and scales of short mRNA
  • Flexible choice of approaches depending on the use of mRNA
  • Available of both research-grade and GMP-grade mRNA
  • Scalable and standardized processes
  • Sterility and bioburden controls
  • Reliable lab report with timely update
  • High-quality services with competitive prices

Based on our extensive experience in dealing with a variety of mRNA, Creative Biolabs could produce custom-made synthetic short lengths mRNAs to meet our customers' specific demands. For ordering and more information, please send an email to contact us. Our support team will review and provide a quotation soon.

For Research Use Only.