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Custom Chemical Synthesis of mRNA

Creative Biolabs is one of the global companies to support our customers' projects. With the latest instruments and professional staff, we are dedicated to offering first-class chemical synthesis mRNA services to meet your specific goal in a time-saving manner.

Chemical Synthesis of mRNA

Modified mRNAs can readily be obtained from any DNA template using RNA polymerases in a short time. However, mRNA prepared by enzymatic synthesis may have transcription errors that allow it to be produced only on a laboratory scale, and the product may not be pure enough for its intended use. An efficient scalable non-enzymatic (chemical) method for mRNA production could solve these problems. Chemical synthesis of single-stranded mRNA molecules is a widely used laboratory procedure that is an alternative strategy of mRNA synthesis for RNA research as well as RNA biopharmaceuticals. This technique is versatile and allows the researcher to tailor the synthesis of short fragments of mRNA and introduce modifications to mRNA.

Structural mRNA feature.Fig.1 Structural mRNA feature.

Chemical-synthesized RNA can be used for the development of mRNA vaccines, genome editing tools, and mRNA amplification-based diagnostics. Creative Biolabs can assemble mRNA strands by solid-phase synthesis and generate a large number of modified RNAs that can be further improved in purity by conventional methods. According to customer needs, we can provide custom mRNA chemical synthesis services, a wide range of post-transcriptional modifications, various purification options, and suites of analytical services. Additionally, our comprehensive quality control system ensures a robust manufacturing process to provide our customers with excellent and consistent lot-to-lot quality.

Advantages of Our Services

  • Strong technology support to produce high-quality custom-manufactured mRNA
  • Experienced staff and advanced technologies
  • Guaranteed quantity and scales of short mRNA
  • Flexible choice of approaches depending on the use of mRNA
  • Available of both research-grade and GMP-grade mRNA
  • Scalable and standardized processes
  • Sterility and bioburden controls
  • Reliable lab report with timely update
  • High-quality services with competitive prices

Based on our extensive experience in dealing with a variety of mRNA, Creative Biolabs could produce custom-made synthetic short lengths mRNAs to meet our customers' specific demands. For ordering and more information, please send an email to contact us. Our support team will review and provide a quotation soon.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.