Creative Biolabs offers top-tier MLVLP production and RNA delivery services, including custom aptamer design, ensuring precise and efficient gene delivery with high specificity.
In recent years, retroviral-like particles (VLPs) have gained attention as promising tools for various applications in molecular biology and biotechnology due to their unique properties. Unlike traditional retroviral vectors, VLPs are devoid of viral genetic material, thereby minimizing the risk of genomic integration and unwanted genetic alterations in host cells. One notable example of VLPs is the Murine Leukemia Virus-like particles (MLVLPs), which have emerged as efficient carriers for delivering mRNAs into target cells. MLVLPs offer a safe and effective alternative for gene delivery, particularly in applications where transient expression of exogenous genes is desired without the risk of genomic integration. A key strategy employed in utilizing MLVLPs for RNA delivery involves the incorporation of specific RNA aptamers and their corresponding aptamer-binding proteins (ABPs) into the particle structure. RNA aptamers are brief, single-stranded RNA molecules characterized by their high affinity and specificity towards target molecules. These aptamers can be engineered to bind to various proteins with exceptional specificity, making them valuable tools for targeted delivery applications. Creative Biolabs provides several pairs of RNA aptamers and ABPs, which have been successfully employed in MLVLP-mediated RNA delivery systems. For example:
Each aptamer is specifically designed to bind with high affinity to its corresponding ABP, facilitating the efficient encapsulation of RNA cargo within the MLVLP structure. This selective binding ensures precise delivery of the desired RNA payload to target cells or tissues, enhancing the efficacy and specificity of gene delivery applications.
Creative Biolabs is dedicated to providing top-tier MLVLPs services globally. Our services encompass MLVLPs production, purification, and titer titration, alongside comprehensive offerings for aptamer design and synthesis. Reach out to us for further details, and we assure you of our unparalleled service quality.
Inquire About Our ServicesA: MLVLPs are retroviral-like particles without viral genetic material, used for safe and efficient RNA delivery in molecular biology.
A: MLVLP is safer than traditional retroviral vectors because it is replication-deficient, reducing the risk of insertional mutagenesis and limiting unintended gene integration, making it a more controlled option for gene therapy.
A: MLVLP is suitable for gene therapy, vaccine development, and functional genomics studies, offering efficient gene delivery with reduced safety risks, particularly in applications requiring stable gene expression without replication.
A: MLVLP achieves targeted RNA delivery by incorporating specific ligands or surface modifications on the viral particles, enabling precise binding and entry into target cells, ensuring efficient and localized gene expression.
A: Services include MLVLP production, purification, titer titration, and aptamer design and synthesis.
| Cat. No | Product Name | Promoter |
|---|---|---|
| GTVCR-WQ001MR | IVTScrip™ pT7-mRNA-EGFP Vector | T7 |
| GTVCR-WQ002MR | IVTScrip™ pT7-VEE-mRNA-EGFP Vector | T7 |
| GTVCR-WQ003MR | IVTScrip™ pT7-VEE-mRNA-FLuc Vector | T7 |
| GTVCR-WQ004MR | IVTScrip™ pT7-VEE-mRNA-mCherry Vector | T7 |
| Cat. No | Product Name | Type |
|---|---|---|
| GTTS-WQ001MR | IVTScrip™ mRNA-EGFP (Cap 1, 30 nt-poly(A)) | Reporter |
| GTTS-WQ002MR | IVTScrip™ mRNA-EGFP, 5-Methoxy-U modified (Cap 1, 30 nt-poly(A)) | Reporter |
| GTTS-WQ003MR | IVTScrip™ mRNA-EGFP, 5-Methoxy-U, Cyanine 5-U modified (Cap 1, 30 nt-poly(A)) | Reporter |
| GTTS-WQ004MR | IVTScrip™ mRNA-Fluc (Cap 1, 30 nt-poly(A)) | Reporter |
