From the 1950s, PEGs were widely explored as separation and purification aids, matrices for embedding, anti-freeze, lubricants for medical devices, food additives, and as vehicles in dermatological applications, suppositories, parenteral, tablets, and pills. Colloidal science further re-birthed PEG, as a classical steric stabilizer that is capable to escape from the host's immune defense system. DPPE-PEG2000 is one of the many classifications of PEG, the structure is as follows:
Fig.1 Chemical structure of DPPE-PEG2000.
The previous experimental investigation of the size and permeability of PEG2000 grafted vesicles yields two essential results - the spontaneous decrease of the mean size of the vesicles at temperatures above the temperature of the main phase transition of the predominant lipid component and the increased permeability of the vesicles in the range of the transition of the grafted polymer from the mushroom into the brush conformation. These effects may be useful in practice for the preparation of drug delivery systems. For example, vesicles containing 1 mol% DPPE-PEG2000 have a reduced permeability relative to PEG-free vesicles at 37 oC although 1 mol% DPPE-PEG2000 is below the range normally used for steric stabilization in vivo.
In another research, DPPE-PEG microparticles and nanoparticles with differing PEG lengths were rationally designed and successfully produced using the advanced organic spray-drying process in the closed mode for dilute alcohol solutions. These novel particles as aerosolized dry powders of lung surfactant-mimic and biocompatible lipopolymeric microparticles/nanoparticles offer the potential to be used in the delivery of a wide variety of pulmonary drugs, owing to their inherent ability to encapsulate numerous types of drugs, controlled drug release, enhanced mucus penetration by phospholipid spreading and PEG penetration, and evasion of phagocytosis by immune cells.
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