PEGylated stearyl is an amphiphilic, PEG surfactant, and can be used for drug delivery systems to enhance drug solubility. As a leader in this field, Creative Biolabs can help scientific researchers improve the efficiency of experiments.
Fig. 1 Structure of PEG conjugates with stearic acid. (Tarahovsky, 2010)
Doxorubicin is an anthracycline drug with a broad anti-tumor spectrum, but it can cause toxic and side effects. Liposome doxorubicin is a liposome as a shell to encapsulate common doxorubicin. Numerous colloidal carriers of doxorubicin have been studied as delivery systems to limit the side effects of the drug. So the stealth solid lipid nanoparticles were prepared, containing doxorubicin as an ion-pair complex. Stearic acid-PEG 2000 was used as a stealth agent to modify the stealth solid lipid nanoparticles.
Some research results indicated that vinca alkaloid drugs were successfully encapsulated into solid lipid nanoparticles. Many reports have indicated that while the conventional liposomes carriers had a short elimination half-life, the PEG modification of drug carriers had a much longer half-life indicated that the PEG modification carriers could greatly improve the accumulation of lipophilic anticancer drugs in tumor tissues. PEG-modified solid lipid nanoparticles modified by PEG2000-SA were achieved from the cold homogenization technique. In conclusion, PEG-modified solid lipid nanoparticles loading vinca alkaloid drugs were demonstrated to be an ideal carrier with good biocompatibility.
Solid lipid nanoparticles can be actively engineered as a potential nanoparticle carrier for the oral drug. There are many difficulties in developing an efficient nanocarrier for oral administration. Some studies presented that compared to the conventional solid lipid nanoparticle, PEGylated solid lipid nanoparticle presented improved absorption efficiency and prolonged blood circulation times. The solid lipid nanoparticles were prepared by the aqueous solvent diffusion method, subsequently modified with PEG2000-stearic acid.
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