Dodecanoic acid, also called lauric acid, is a saturated fatty acid with a 12-carbon atom chain and thus has many properties of medium-chain fatty acids. It is a bright white, powdery solid with a faint odor of bay oil or soap. The salts and esters of lauric acid are called laurates.
Fig.1 Ball-and-stick model of the lauric acid molecule, C12H24O2, AKA dodecanoic acid.
The hydrophobic partial fatty acid (FA, lauric acid) was coupled to the NH2 position of OCMCh using NHS and EDC to form the hydrophobic drug delivery vector OCMCh-FA (OCF). PTX was then encapsulated into the OCF micelle through hydrophobic interactions. Transferrin/PEG/O-carboxymethyl chitosan/fatty acid/paclitaxel (TPOCFP) micelles a hydrophobic drug carrier with low cytotoxicity, sustained release, high cellular uptake, and site-specific targeted delivery. The TPOCFP micelles are spherical with a particle size of 140-649 nm. Drug release from TPOCFP micelles was less than 50% over 48h. The TPOCFP micelle is non-toxic and has significant anticancer activity, as indicated by the MTT assay using a variety of cancer cell lines. The research indicates that the TP-conjugated TPOCFP micelles can serve as an effective treatment for solid tumors by targeting delivery and reducing toxicity and side effects of hydrophobic drugs.
Fig.2 Schematic illustration of PTX-encapsulated TPOCFP for hydrophobic drug delivery. (Nam, 2013)
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