Myristic acid (MC) is a common saturated fatty acid with the molecular formula CH3(CH2)12COOH. MC is often added to the N-terminus glycine in receptor-associated kinases to determine the membrane localization of the enzyme.
Fig.1 Ball-and-stick model of myristic acid.
MC is a fatty acid with high hydrophobicity, which is sufficient to be added into the fatty acyl core in the phospholipid bilayer of the eukaryotic plasma membrane of the cell, thus acting as a lipid anchor to biomembranes and increasing cellular uptake. It can increase the brain uptake, as demonstrated by the successful transport of myristoylated polyarginine crossing the BBB and resulting in significant accumulation in the neuron. The brain tumor-targeting capability of MC has been proven by scientists, who modified polyethylene glycol (PEG) with MC to increase the brain uptake, transfection, and gene expression using polyethyleneimine (PEI) as the gene carrier in vitro and in vivo. The significant effect of MC on the translocation of the delivery system into the brain tissue indicated the potential of MC as a potent ligand in the design of brain-target drug delivery systems.
Fig.2 Brain uptake of MC-PEI-IR820. (Meng, 2010)
Creative Biolabs is a world-leading biotechnology company that has been studied on mRNA research for years. Our team of highly qualified and experienced technical staff will work with you to develop mRNA delivery strategy based on MC to add value to your product or project. Please contact us for more information and a detailed quote.
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