Trimyristin (TM) is an ester with the chemical formula C45H86O6. It is a saturated fat which is the triglyceride of myristic acid. TM is a white to yellowish-gray solid that is insoluble in water, but soluble in ethanol, benzene, chloroform, dichloromethane, and ether. The solid triglyceride TM (bulk melting point 56oC) exhibits strong supercooling in the nanoparticulate state. Therefore, TM nanoparticles remain liquid after preparation by melt-homogenization and crystallize only below room temperature.
Fig.1 Skeletal formula of TM.
Solid lipid nanoparticles (SLN) were prepared by w/o/w emulsion technology. The particles were composed of solid lipid TM and surfactant poloxamer 407 for oral transport of salmon calcitonin. The average particle size of TM SLN is 200 nm and the association efficiency with calcitonin is about 86%. At the dose of 500 IU / kg, SLN can reduce the basic blood calcium level by 20% and last for more than 8 hours. The results showed that the combination of salmon calcitonin and TM SLN was the key factor to improve the efficiency of oral delivery protein.
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