Glyceryl Tripalmitate/Tripalmitin

Tripalmitin is a triglyceride derived from the fatty acid palmitic acid. The molecular formula is C₅₁H₉₈O₆, a colorless needle crystal, often used in cosmetics and pharmaceuticals, but also for leather processing finishing.

Fig.1 Skeletal formula of tripalmitin.

Tripalmitin as Modifiers in the Crystallisation of Palm Oil

Tripalmitin and monoacylglycerols are modifiers in the crystallisation of palm oil. The addition of tripalmitin heightened the speed of crystallisation, the increase in solids content, the release of thermal energy, the increase in the size of the triacylglycerol crystals, and the formation of b-crystals.

Fig.2 Microscopic images under polarised light at 25^oC of refined palm oil, refined palm oil with added tripalmitin and refined palm oil with added monoacylglycerols: Po; PoTp1; Po2Tp2; PoMp; PoMBe. (Basso, 2010)

Tripalmitin Nanoparticle Formulations Significantly Enhance Paclitaxel Antitumor Activity

Solid lipid nanoparticles (NPs) were prepared by modifying Tripalm-NPs-PTX with hexa (ethylene glycol), β-cyclodextrin, and macelignan. All NPs-PTX formulations showed good hemocompatibility and significantly improved PTX antitumor activity in human breast and lung cancer cells. Tripalmitin NPs (Tripalm-NPs) have already been used to deliver 5-fluorouracil, tamoxifen citrate, and curcumin with a high entrapment efficiency. Tripalm-NPs can be combined with antibodies to improve the efficacy of the anticancer drugs. The recent development of new formulations of solid lipid NPs, including tripalmitin, has increased the possibility of transporting low solubility drugs.

Fig.3 Tripalmitin NP-loading PTX morphology, size, and chemical characterization. (Leiva, 2017)

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References

1. Basso, R.C.; et al. Tripalmitin and monoacylglycerols as modifiers in the crystallisation of palm oil. Food chemistry. 2010, 122(4): 1185-1192.
2. Leiva, M.C.; et al. Tripalmitin nanoparticle formulations significantly enhance paclitaxel antitumor activity against breast and lung cancer cells in vitro. Scientific reports. 2017, 7(1): 1-15.