Caprylic/capric triglyceride is the triglycerides and esters isolated from fractionated vegetable oil, and fatty acids isolated from coconuts and palm kernel oils. It has good oxidation stability and can be used as a food additive and cosmetic, as well as thickeners or penetration accelerators. Caprylic/capric triglyceride is a transparent, non-viscous liquid. As we all know, it can improve the spreadability of the formula.
Fig.1 Chemical structure of caprylic capric triglyceride. (López, 2015)
The researchers developed an optimized ceramide-based NLC prescription for ILTG and evaluated its potential as a transdermal delivery system. ILTG-loaded NLCs were prepared by mixing solids (ceramides, cholesterol) and liquid lipids (caprylic acid/caprylic triglycerides) in varying proportions using thermal homogenous and ultrasonic treatment. The results showed that the particle size of the formulation was 150.19-251.69 nm with a ZP>-20mV. The EE% was 56.45-89.97%. Increasing the content of caprylic/capric triglyceride (liquid lipid) increased the ZP value. This is attributable to the increase in the number of carboxylic groups in the caprylic/capric triglyceride. The ILTG-NLCs and ILTG-nanoemulsion (NE) both improved the skin permeation of ILTG. However, the skin permeation of NLC was higher than that of the NE owing to the ceramide content. Based on this, normal skin or skin lacking in ceramide could be a promising vehicle for the transdermal delivery system of ILTG.
Fig.2 Transmission electron microscopy (TEM) images of isoliquiritigenin-loaded nanostructured lipid carrier (ILTG-NLCs) and ILTG-NE. (Noh, 2017)
Creative Biolabs offers well-established and innovative one-stop-shop mRNA products and solutions. You can count on our skilled and passionate workforce to find the most suitable path and to guide you through your research journey. We can make your mRNA delivery journey easier. Please contact us for more information and a detailed quote.
References
