Caprylic/capric triglyceride is the triglycerides and esters isolated from fractionated vegetable oil, and fatty acids isolated from coconuts and palm kernel oils. It has good oxidation stability and can be used as a food additive and cosmetic, as well as thickeners or penetration accelerators. Caprylic/capric triglyceride is a transparent, non-viscous liquid. As we all know, it can improve the spreadability of the formula.
The researchers developed an optimized ceramide-based NLC prescription for ILTG and evaluated its potential as a transdermal delivery system. ILTG-loaded NLCs were prepared by mixing solids (ceramides, cholesterol) and liquid lipids (caprylic acid/caprylic triglycerides) in varying proportions using thermal homogenous and ultrasonic treatment. The results showed that increasing the content of caprylic/capric triglyceride (liquid lipid) increased the ZP value. This is attributable to the increase in the number of carboxylic groups in the caprylic/capric triglyceride. The ILTG-NLCs and ILTG-nanoemulsion (NE) both improved the skin permeation of ILTG. However, the skin permeation of NLC was higher than that of the NE owing to the ceramide content. Based on this, normal skin or skin lacking in ceramide could be a promising vehicle for the transdermal delivery system of ILTG.
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