Creative Biolabs is one of the well-recognized experts who are professionals in the field of mRNA delivery. Now, we are proud to offer a series of liquid lipid products for mRNA delivery, including but not limited to soya bean oil, oleic acid, caprylic/capric triglyceride, α-tocopherol/vitamin E, squalene, and isopropyl myristate.
In the last decade, there has been a tremendous increase in studies involving nanostructured lipid carriers (NLCs). NLCs potentially improve the availability of poorly water-soluble drugs and protect labile drugs from degradation and metabolism. NLCs are typically developed to overcome the potential problems related to solid lipid nanoparticles (SLNs), limited in their drug loading capacity and potential drug expulsion during storage. Instead of taking solid lipids as the lipid matrix for SLNs, the NLCs are produced by incorporating liquid lipids (oils) in solid lipids, which leads to more imperfections in the crystal structures and contributes to a sustained release formulation and higher drug incorporation and drug release. Their amicable physicochemical and biopharmaceutical properties have been widely studied to deliver many small and large molecules.
Fig.1 Structure of liquid nanoemulsions and solid lipid nanoparticles. (Weiss, 2008)
A number of different lipids and surfactants have been utilized in NLC formulations with different sizes and zeta potentials. Liquid lipids investigated include many types, such as:
The choice of liquid lipid has a significant influence on the physicochemical characteristics and stability of NLCs. Dispersion stability is enhanced when the oil concentration is increased, which leads to enhancing their suspension stability. In addition, the increased drug loading capacity and decreased burst release are related to the presence of liquid lipid in the NLC structures.
Increasing the liquid lipid content is shown to alter the zeta potential but not the particle size of NLCs in one study. The increased solubilization of the liquid lipid component allows for more significant loading of the action in the NLCs and thus greater deposition. Overall, liquid lipids are a prerequisite for the successful formulation of stable NLCs with predictable biopharmaceutical properties for the delivery of various bio-actives for delivery applications.
If you are interested in our products, please do not hesitate to contact us for more detailed information.