Creative Biolabs is one of the well-recognized experts who are professionals in the field of mRNA delivery. Now, we are proud to offer a series of reagents for mRNA delivery, such as cationic lipids.
The past two decades have witnessed the utilization of liposomes as synthetic non-viral vectors in gene delivery and drug delivery. Lipid nanoparticle systems can be stabilized with surfactants and cosurfactants such as cationic lipids. It is possible that such components promote particle penetration and enhance formulation retention time and in vivo performance when compared with negatively charged liposomes. The presence of a positive charge enables cationic lipids to interact strongly with anionic surfaces such as bilayer membranes of biological cells. As a result, they can modify the properties of the surface at which they are adsorbed.
CPC is an amphiphilic quaternary compound that consists of quaternary nitrogen connected with one or more hydrophobic side chains. It is a well-known cationic surfactant that facilitates binding to negatively charged surfaces. Valuable properties of CPC include solubility in water and alcohol and its ability to reduce surface tension. It has wide-ranging applications, such as drug delivery vehicles, for catalysis, nanoreactors, and antibacterial (antiseptic) drugs.
Fig.1 CPC-based drug carries. (Mirtič, 2020)
Nanocarriers are considered particularly suited for the administration of drugs with low bioavailability and poor water solubility. Previously, researchers reported on the CPC as a crosslinker of alginate to form stable complex nanoparticles. In these systems, the CPC surfactant increases the solubility of the drug at concentrations below its critical micellar concentration and crosslinks the polyelectrolyte to form nanoparticles. These innovative carriers can be used to solubilize poorly soluble drugs and enable the design of more effective delivery carriers for local, oral, or parenteral delivery.
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