Creative Biolabs is always dedicated to assisting our clients with the most satisfactory mRNA delivery-related solutions. Now, we are proud to offer a series of reagents for mRNA delivery, such as cationic lipids, to meet your requirement.
Recent drug-delivery approaches employ positively charged microparticles to deliver negatively charged macromolecular therapeutics such as DNA, oligonucleotides, and proteins. Cationic lipids are amphiphilic molecules, implying that they consist of a hydrophilic and a hydrophobic region, i.e., a (charged) cationic (amine) headgroup, attached via a linker (glycerol) to a double hydrocarbon chain or a cholesterol derivative, respectively. So far, cationic lipids as a component for gene delivery vehicles have become a powerful research tool for transferring exogenous genetic material into host cells.
Fig.1 A representation of the various steps involved in gene transfection by cationic lipids. (Martin, 2005)
An ideal cationic lipid for gene delivery should be efficient and non-toxic, forming highly stable particles with genes and facilitating the nuclear localization of genes. SA is a cationic lipid with surface-active properties commonly used to produce positively charged liposomes or emulsions. It has been applied to induce a positive charge in the liposomal bilayers and successfully form a potential gene transfer vehicle.
For example, SA and cholesterol (Chol) at equimolar ratio form stable large unilamellar vesicles with a high positive charge and limited permeability. Compared to other cationic liposomes, the transfer vehicle formulated with SA and Chol could be a better candidate for gene delivery due to their higher positive surface charge and significantly increased particle stability. They show some excellent advantages: (1) both components are small molecules, which are much easier to obtain and purify compared to macromolecules (e.g., polymers); (2) it would be easy for this system to scale up to meet the industry requirements.
If you are interested in our products, please do not hesitate to contact us for more detailed information.
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