Egg Phospholipid (Lipoid E 80, Lipoid E 80 S)

Creative Biolabs is one of the well-recognized experts who are professional in applying advanced platforms for the development of drug delivery systems. Now we are proud to offer a series of reagents, such as egg phospholipid (Lipoid E 80, Lipoid E 80 S) to achieve more functions.

Introduction of Egg Phospholipid

Egg phospholipids, also known as egg lecithin, are primarily a mixture of naturally occurring phospholipids that are isolated from the egg yolk. The major component of egg phospholipid is phosphatidylcholine which is one of the important components of the phospholipid portion of the cell membrane and almost occurs in all cellular organisms. In addition, phosphatidylethanolamine and sphingomyelin are also important components of egg phospholipid.

Depending on hydration and temperature, egg phospholipids can form micelles, liposomes, bilayer sheets, and lamellar structures in an aqueous solution. This results in a type of amphipathic surfactant.

Applications of Egg Phospholipid

The characterization of emulsification and lubricant make egg phospholipid a novel surfactant. In the pharmaceutical industry, it is a good dispersing agent that helps in emulsification and encapsulation. In the cosmetics industry, it can be used to produce stable O/W emulsions for cosmetic compositions or pharmaceutical excipients.

Using the ethanol injection method, the liposomes contain phospholipid (Lipoid E 80 or POPC) and stabilizers (cholesterol, stearic acid, or cocoa butter) can be constructed. The mean particle size obtained via Lipoid E 80 and POPC liposomes was 84 and 59 nm under optimal conditions. When Lipoid E 80 liposomes were loaded with vitamin E, high entrapment efficiency of 99.87% can be achieved. Obtained from egg yolk lecithin, the Lipoid E 80 using here contains 82% of phosphatidyl-choline and 9% of phosphatidyl-ethanolamine.

Fig 1. TEM images of drug-free liposomes prepared using Lipoid E80 (a) or POPC (b) and drug-loaded liposomes (c). (Laouini, 2013)

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Reference

1. Laouini, A.; et al. Preparation of liposomes: a novel application of microengineered membranes-investigation of the process parameters and application to the encapsulation of vitamin E. RSC advances. 2013, 3(15): 4985-4994.