Creative Biolabs is one of the well-recognized experts who are professional in applying advanced platforms for the development of drug delivery systems. Now we are proud to offer a series of reagents, such as Soy Phospholipid (Lipoid S 75) to achieve more functions.
Soy Phospholipid (Lipoid S 75) consists of fat-free soybean phospholipids with 70% phosphatidylcholine. As a novel amphoteric surfactant, it has been widely used in drug delivery systems.
Lipoid S 75 has been used as a surfactant for the development of lipid nanoparticle (LN) dispersions to encapsulate hydrophilic proteins or drugs.
In recent studies, lipoid S 75 has been used to produce fractionated coconut oil-based Solid Lipid Nanoparticles (SLNs) of Acyclovir (ACV). According to various characterization techniques, including X-Ray Diffraction (XRD), Fourier transform infrared study (FTIR), master sizer analysis, and zeta potential, it is found that the zeta potential of the Lipoid S75 batch is 23.23mV. Compared with conventional Glyceryl monostearate (GMS) and tween 80 nanoparticles, the novel lipoid S and Pluronic F68 nanoparticles present more advantages in particle size, stability, and zeta potential. The SLN dispersions with the average size in the nano range have high encapsulation efficiency and loading capacity, as well as a predetermined in vitro drug release profile.
Liposomes are effective nano-delivery devices for the improvement of physicochemical stability and biological efficacy of the encapsulated peptides and proteins. Here, the lipoid S 75-biopeptides nanocomposites were produced through both conventional and direct heating methods (DHMs). The results showed lipoid S 75-based liposomes can be used as effective carriers to improve the physicochemical stability, bioavailability, and efficacy of food biopeptides as potential therapeutic ingredients for incorporation into functional foods.
Fig 1. Transmission electron microscopy of the Lipoid S75-biopeptides nanoliposome composite prepared by conventional method (BLS75-CM) and Lipoid S75-biopeptides nanoliposome composite prepared by direct heating method (BLS75-DHM). (Auwal, 2018)
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