Photon Correlation Spectroscopy

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With the rapid development of the drug delivery system, lipid nanocapsules are getting more and more attention for effective drug delivery since drug-loaded nanoparticles provide an ideal solution to overcome the severe side effects. Photon correlation spectroscopy (PCS) is widely regarded as a promising tool for determinating lipid nanocapsules. Creative Biolabs is very experienced in this field and can provide quality services according to customer needs.

Instruction of Photon Correlation Spectroscopy

In recent years, much attention has been focused on lipid nanocapsules that are emerging as safe delivery vehicles due to their causative role in drug delivery. It is worth noting that particle size characteristics are crucial factors in the behavior of nanoparticulate drug delivery systems. Therefore, it is necessary to make an exact determination of the parameters to ensure the effect. Several techniques are applied in the size determination of nanoparticles, and PCS analysis was able to characterize mixed samples of particle batches differing in their average size. The PCS is mainly used to monitor the average particle size and polydispersity of particles dispersed in the liquid. Brownian motion causes the position and orientation of each scatter to change with time. The light scattered by the particles is continuously measured at a certain angle. Based on the theoretical relationship between the brownian motion and the size of spherical particles, the data are processed to get the size of the particles.

Schematic view of photon correlation spectroscopy.Fig.1 Schematic view of photon correlation spectroscopy. (Hodoroaba, 2019)

Applications of Photon Correlation Spectroscopy

The particle size characteristics are essential for nanocapsules drug delivery systems since these parameters can significantly modify physicochemical as well as biopharmaceutical behavior. Nowadays, PCS is the standard method to determine the particle diameter and size distribution of nanoparticles. An important example is the lipophilic antipsychotic drug-clozapine. Solid lipid nanoparticle delivery systems of clozapine have been developed, and the particle size and zeta potential were measured by PCS. In addition, lipid nanocapsules with different compositions were used for topical delivery of resveratrol. Some studies have observed that depending on the different lipid compositions, different release profiles may be obtained. Moreover, lipid composition could also have an important effect on the permeation ability of the drug. A variety of lipid nanocapsules with different compositions were prepared and characterized by particle size. The mean particle size, polydispersity index, and zeta potential of all formulations were analyzed by PCS.

The geometry, size, and property of the liposomes in an aqueous environment are the key influencing factors for the potential applications of these systems as drug carriers. For this reason, a wide variety of techniques and methods have been proven to be excellent tools to characterize liposomes. We have professional techniques to help you solve the drug-related problems in the project, please contact us to learn more about our services.


  1. Hodoroaba, V. D.; et al. Characterization of Nanoparticles: Measurement Processes for Nanoparticles. Elsevier. 2019.
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