Creative Biolabs is one of the well-recognized experts who are professional in applying advanced platforms and have extensive experience in mRNA therapeutics. To achieve efficient and safe delivery of mRNA, now we are proud to offer a series of reagents, such as ionic surfactants.
A surfactant is a substance with surface activity. Its molecular structure has two parts: lipophilic (hydrophobic) and hydrophilic (oleophobic). It can be adsorbed on the two-phase interface and arranged in a single molecule to reduce the surface tension of the solution. According to whether the hydrophilic group generates ions and its electrical properties after the surfactant is dissolved in water, it is divided into four types: anionic, cationic, zwitterionic, and nonionic surfactants.
Ionic surfactants, also known as ionic emulsifiers, are a class of substances that can form micelles. The molecular always contain both ionic hydrophilic groups and lipophilic groups. The hydrophilic groups of anionic surfactants are negatively charged with a wide variety of types, mainly including carboxylates, sulfate ester salts, sulfonates, and acyl amino acids. The hydrophilic groups of cationic surfactants are positively charged, such as quaternary ammonium salts.
In recent years, ionic surfactants have been widely used in different technical fields, such as medicine, pesticides, cosmetics, and food industries.
Because of its key role in effectively protecting mRNA and transporting it to the cell, lipid nanoparticles (LNPs) have been served as promising vehicles in a variety of therapeutics. To solve the problem of low efficiency in embedding drugs, solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were developed. In general, SLN and NLC are composed of lipids and stabilizing agents, including surfactants and other coating materials. Surfactants can reduce the interfacial tension between the lipid and the water phase and improve the stability of the resulting formulation.
Fig 1. Suggested structures of lipid nanoparticle nucleic acid carriers. (Tenchov, 2021)
Equipped with world-leading technology platforms and professional scientific staff, we are pleased to offer the most qualified products for our customers all over the world. If you are interested in our products or services, please do not hesitate to contact us for more detailed information.
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