Creative Biolabs has been a long-term expert in the field of mRNA therapeutics. To achieve efficient and safe delivery of mRNA, now we are proud to offer a series of reagents, especially sodium cholate.
Sodium cholate (NaC) is one kind of bile salt formed by the combination of bile acid and sodium ion. NaC is composed of a large, rigid, and hydrophobic steroid core, hydrophilic moieties of three hydroxyl groups, as well as an ionic head of a carboxyl group. As an anionic, non-denaturing detergent and surfactant, its amphiphilic nature is very different from ordinary aliphatic surfactant molecules. In protein research, it has been used for the extraction of membrane receptors and other plasma membrane proteins.
Because of their amphiphilic properties, bile acids have been widely applied in the development of micelle-based drug delivery systems. The steroidal structure is the benefit to induce hydrophobic interaction with drugs, so that improve drug-loading efficiency. What’s more, the intermolecular hydrogen contributes to the complementary mechanism of the micellization process. Due to synergistic interactions, bile acids can be combined with polar lipids, conventional surfactants, or amphoteric drugs to form mixed micelles, with improved solubilization and lower critical micelle concentration (CMC).
In recent studies, the phospholipid/sodium cholate hybrid system is used to study the self-assembly of micelles and the formation of micellar systems. This type of micellar system is used for drug delivery through the skin. In addition, NaC-enhanced polymeric micelle systems have been applied for tumor-targeted delivery of paclitaxel. Ethosomes complex modified by polyethyleneimine and NaC can be served as multidrug carriers for the treatment of melanoma.
Fig 1. Preparation of PTX-CMs and the fate of PTX-CMs in vivo. CMs, sodium cholate and mPEG-block-poly (d,l-lactide) micelles. (Zhang, 2017)
As a pioneer and the undisputed global leader in mRNA therapeutics, we are pleased to use our extensive experience and advanced platform to offer the best service and the most qualified products to satisfy each demand from our customers. If you are interested in our products or services, please do not hesitate to contact us for more detailed information.
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